Tender Details
Tender Title / Description
| Tender Title | Consultancy services to carry out Non-GLP Determining if the Compound-1348 is a Substrate of the Transporters 1. P-gp 2.BCRP along with 3.Permeability assessment using Caco2 assay system |
|---|---|
| Tender Description | non-glp determining if the compound-1348 is a substrate of the transporters (i) p-gp, (ii) bcrp along with it’s (iii) permeability assessment using caco2 assay system [n=3, using standard compounds, substrates and inhibitors]note 1: n=3 or triplicate well [apical to basal and basal to apical permeability]note 2: use at least three standard compounds covering low to high permeabilitynote 3: standard substrate at least one each for p-gp and bcrpnote 4: standard inhibitor at least one each for p-gp and bcrpnote 5: membrane integrity test should be performednote 6: data type: papp value, % recovery, permeability rank, efflux ratio, efflux ratio in presence and absence of inhibitor, etc |
| Comments | non-glp determining if the compound-1348 is a substrate of the transporters (i) p-gp, (ii) bcrp along with it’s (iii) permeability assessment using caco2 assay system [n=3, using standard compounds, substrates and inhibitors]note 1: n=3 or triplicate well [apical to basal and basal to apical permeability]note 2: use at least three standard compounds covering low to high permeabilitynote 3: standard substrate at least one each for p-gp and bcrpnote 4: standard inhibitor at least one each for p-gp and bcrpnote 5: membrane integrity test should be performednote 6: data type: papp value, % recovery, permeability rank, efflux ratio, efflux ratio in presence and absence of inhibitor, etc |
Important Dates
| Published Date | |
|---|---|
| Due Date | 26 Dec 2024 00:00:00 |
Estimate and EMD
| Estimated Value | 0.0 |
|---|---|
| EMD | 0 INR |
| Processing Fee | 0 INR |