Description: Consultancy services to carry out Non GLP Determining if the Compound 1348 is a Substrate of the Transporters 1 P gp 2 BCRP along with 3 Permeability assessment using Caco2 assay system Name of Work Consultancy services to carry out Non GLP Determining if the Compound 1348 is a Substrate of the Transporters i P gp ii BCRP along with it s iii Permeability assessment using Caco2 assay system n 3 using standard compounds substrates and inhibitors
Details: Non-GLP Determining if the Compound-1348 is a Substrate of the Transporters (i) P-gp, (ii) BCRP along with it’s (iii) Permeability assessment using Caco2 assay system [n=3, using standard compounds, substrates and inhibitors]Note 1: n=3 or triplicate well [Apical to Basal and Basal to Apical permeability]Note 2: Use at least three standard compounds covering low to high permeabilityNote 3: Standard Substrate at least one each for P-gp and BCRPNote 4: Standard Inhibitor at least one each for P-gp and BCRPNote 5: Membrane integrity test should be performedNote 6: Data type: Papp value, % Recovery, permeability rank, efflux ratio, efflux ratio in presence and absence of inhibitor, etc
Sector: Industry Development